Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (4): 922-929.DOI: 10.6023/cjoc201910011 Previous Articles     Next Articles


徐炜刚, 黄丹凤, 王克虎, 赵芳霞, 赵转霞, 虎永琴, 苏瀛鹏, 胡雨来   

  1. 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2019-10-11 修回日期:2019-12-10 发布日期:2019-12-27
  • 通讯作者: 胡雨来
  • 基金资助:

Study on the Hydrocyanation Reaction of Trifluoromethylated Acylhydrazones

Xu Weigang, Huang Danfeng, Wang Kehu, Zhao Fangxia, Zhao Zhuanxia, Hu Yongqing, Su Yingpeng, Hu Yulai   

  1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2019-10-11 Revised:2019-12-10 Published:2019-12-27
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21662030, 21861033).

The Lewis acid catalyzed 1,2-addition reaction of trifluoromethylated acylhydrazones with trimethylsilyl cyanide was investigated, and a series of cyanohydrazide compounds containing trifluoromethyl group were afforded in high yield. The method could be easily operated in mild reaction conditions, which provides an efficient method for the synthesis of trifluoromethylated hydrazides with structural diversity.

Key words: trifluoromethylated acylhydrazones, trimethylsilyl cyanide, acylhydrazides, hydrocyanation