Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (8): 2426-2432.DOI: 10.6023/cjoc201912036 Previous Articles     Next Articles


张亚辉, 刘洋, 缪建康, 郝文燕   

  1. 江西师范大学化学化工学院 功能有机小分子教育部重点实验 南昌 330022
  • 收稿日期:2019-12-25 修回日期:2020-05-12 发布日期:2020-05-28
  • 通讯作者: 郝文燕
  • 基金资助:

Copper-Catalyzed Cascade Bicyclization of o-Alkenylphenyl Isothiocyanates with Sodium Azide Leading to the 5H-Benzo[d]tetrazolo[5,1-b] [1,3]thiazines

Zhang Yahui, Liu Yang, Miao Jiankang, Hao Wenyan   

  1. Key Laboratory of Functional Small Organic Molecules, Ministry of Education, College of Chemistry&Chemical Engineering, Jiangxi Normal University, Nanchang 330022
  • Received:2019-12-25 Revised:2020-05-12 Published:2020-05-28
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21762023), the Natural Science Foundation of Jiangxi Province (No. 2018BAB203006) and the Research Fund of Jiangxi provincial Education Department (No. GJJ160285).

A simple and efficient method for the preparation of 5H-benzo[d]tetrazolo[5,1-b] [1,3]thiazines has been developed. The transformation involved the copper(I)-catalyzed cascade bicyclization of o-alkenylphenyl isothiocyanates with sodium azide to afford corresponding products in moderate to good yields. This present strategy provides an effective way to construct small molecular N-, and S-heterocycles.

Key words: copper-catalysis, cascade bicyclization, 5H-benzo[d]tetrazolo[5,1-b] [1,3]thiazine, o-alkenylphenyl isothiocyanate