Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (7): 2120-2126.DOI: 10.6023/cjoc202003021 Previous Articles     Next Articles


刘贵园a, 郭大乐b, 邓赟b, 令狐浪a, 张茂生a, 何芋歧a, 肖世基a   

  1. a 遵义医科大学药学院 贵州遵义 563006;
    b 成都中医药大学药学院 成都 611137
  • 收稿日期:2020-03-08 修回日期:2020-04-23 发布日期:2020-05-08
  • 通讯作者: 肖世基
  • 基金资助:

Lignans from the Heartwood of Nothotsuga longibracteata

Liu Guiyuana, Guo Daleb, Deng Yunb, Linghu Langa, Zhang Maoshenga, He Yuqia, Xiao Shijia   

  1. a School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou 563006;
    b School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137
  • Received:2020-03-08 Revised:2020-04-23 Published:2020-05-08
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 31560102).

3-(4'-Hydroxy-3'-methoxybenzyl)-2(5H)-furanone (1), a rare benzyl furanone derivate, and two new lignans (2 and 3) were isolated from the heartwood of Nothotsuga longibracteata, together with nineteen known lignans compounds. The structures and absolute configurations of the undescribed compounds were elucidated on the basis of HR-ESI-MS, 1D NMR, 2D NMR, and CD spectroscopies. The cytotoxic effects of the isolated new lignan compounds on three human tumour cell lines (A172, SHSY5Y, and Hela) were evaluated by methyl thiazolyl tetrazolium (MTT) assay. Their showed no cytotoxic activities at the concentration of 50 μmol/L. Gastrointestinal motility test of zebrafish showed that compound 3 has the function of promoting gastrointestinal motility of zebrafish to excrete Nile red at doses 8 and 24 μmol/L by means of acting on the cholinergic nervous system.

Key words: pinaceae, Nothotsuga longibracteata, benzyl furanone, lignans