Research Progress in Cancer Treatment by Diketopyrrolopyrrole-Based Photosensitizers and Photothermal Agents

doi:10.6023/cjoc202005041

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (12): 4155-4167.DOI: 10.6023/cjoc202005041 Previous Articles Next Articles

吡咯并吡咯二酮类光敏剂/光热试剂在肿瘤治疗中的应用研究进展

汪凌云, 辛舒琪, 唐浩, 曹德榕

华南理工大学化学与化工学院广州 510640

收稿日期:2020-05-18 修回日期:2020-06-17 发布日期:2020-07-09
通讯作者: 汪凌云 E-mail:lingyun@scut.edu.cn
基金资助:
国家自然科学基金（Nos.21772045，22071065）、广东省自然科学基金（No.2018B030311008）、中国留学基金委员会（No.201906155012）和广州市科技计划（No.201904010414）资助项目.

Research Progress in Cancer Treatment by Diketopyrrolopyrrole-Based Photosensitizers and Photothermal Agents

Wang Lingyun, Xin Shuqi, Tang Hao, Cao Derong

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640

Received:2020-05-18 Revised:2020-06-17 Published:2020-07-09
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21772045, 22071065), the Natural Science Foundation of Guangdong Province (No. 2018B030311008), the China Scholarship Council (No. 201906155012) and the Technology Program of Guangzhou City (No. 201904010414).

Cancer has become one of the major threats to human health in modern society. Phototherapy including photodynamic therapy (PDT) and photothermal therapy (PTT), as a new type of tumor treatment, has received more and more attentions due to its high spatiotemporal precision, noninvasive nature, controllability, low toxicity and repeatable treatment without initial resistance. It is important to obtain a highly efficient and ideal photosensitizer for reactive oxygen species (ROS) generation for PDT. Photothermal agents with high photothermal conversion efficiency are also in urgent need for PTT. Diketopyrrolopyrrole (DPP) is an excellent type of photosensitizer and photothermal reagent because of its good structural planarity, strong electron affinity, simple synthesis, easy structure modification and high molar absorption coefficient. The research progress of DPP-based photosensitizers and photothermal agents in recent year, including structural modification of DPP, the structure-activity relationship, the mechanism of phototherapy and some representative examples is summarized. Finally, a perspective on the future development of phototherapy based on DPP is presented.

Key words: diketopyrrolopyrrole, photodynamic therapy, photothermal therapy, combined therapy

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Wang Lingyun, Xin Shuqi, Tang Hao, Cao Derong. Research Progress in Cancer Treatment by Diketopyrrolopyrrole-Based Photosensitizers and Photothermal Agents[J]. Chinese Journal of Organic Chemistry, 2020, 40(12): 4155-4167.

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吡咯并吡咯二酮类光敏剂/光热试剂在肿瘤治疗中的应用研究进展

Research Progress in Cancer Treatment by Diketopyrrolopyrrole-Based Photosensitizers and Photothermal Agents

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