Visible Light-Induced Synthesis of Polysubstituted Dihydrofurans via Cyclization of Aromatic Aldehydes with Acrylonitriles

doi:10.6023/cjoc202406003

Chinese Journal of Organic Chemistry

ARTICLE

可见光诱导芳香醛与苄烯丙二腈环化合成多取代二氢呋喃

田曈, 陈镤, 黄华文^a,b,*

^a湘潭大学化学学院湘潭湖南 411105;
^b河南师范大学, 化学化工学院, 新乡, 453007

收稿日期:2024-06-03 修回日期:2024-07-03
基金资助:
国家自然科学基金(No. 22071211), 河南师范大学化学化工学院开放基金(No. 2022C02)资助项目.

Visible Light-Induced Synthesis of Polysubstituted Dihydrofurans via Cyclization of Aromatic Aldehydes with Acrylonitriles

Tong Tian, Pu Chen, Huawen Huang^a,b,*

^a College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105;
^bSchool of Chemistry and Chemical Engineering, Henan Normal University. Xinxiang, 453007

Received:2024-06-03 Revised:2024-07-03
Contact: *E-mail: hwhuang@xtu.edu.cn.
Supported by:
National Natural Science Foundation of China (No. 22071211), Open Research Fund of School of Chemistry and Chemical Engineering of Henan Normal University (2022C02).

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Abstract

We report a synthetic method for multi-substituted 4,5-dihydrofuran compounds through tandem Giese addition/cyclization process under visible light-induced photoredox catalysis from aromatic aldehydes and 2-benzylidenemalononitriles. The reaction was carried out in the absence of transition metal catalysts, providing a simple and stereoselective approach for constructing multi-substituted 4,5-dihydrofurans and making it an important supplement to existing methods.

Key words: dihydrofuran, visible light irradiation, Giese reaction, cyclization, aldehydes

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Tong Tian, Pu Chen, Huawen Huang. Visible Light-Induced Synthesis of Polysubstituted Dihydrofurans via Cyclization of Aromatic Aldehydes with Acrylonitriles[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202406003.

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可见光诱导芳香醛与苄烯丙二腈环化合成多取代二氢呋喃

Visible Light-Induced Synthesis of Polysubstituted Dihydrofurans via Cyclization of Aromatic Aldehydes with Acrylonitriles

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