Recent Advances in the Double Hydrophosphination and Hydrophosphinylation of Alkynes

doi:10.6023/cjoc202603007

Chinese Journal of Organic Chemistry Next Articles

REVIEW

炔烃双氢膦(酰)化反应的研究进展

成东婷^a,b, 朱能波^*,b, 鲍红丽^*,a,b,c,d

^a福建师范大学化学与材料学院福建福州 350007;
^b中国科学院福建物质结构研究所结构化学全国重点实验室福建福州 350002;
^c中国科学院大学福建学院福建福州 350002;
^d福州大学化学学院福建福州 350108

收稿日期:2026-03-05 修回日期:2026-04-18
基金资助:
国家自然科学基金(No. 22225107)和福建省自然科学基金(No. 2025J01249)资助项目

Recent Advances in the Double Hydrophosphination and Hydrophosphinylation of Alkynes

Dongting Cheng^a,b, Nengbo Zhu^*,b, Hongli Bao^*,a,b,c,d

^aCollege of Chemistry and Materials Science, Fujian Normal University, Fuzhou, Fujian Province, 350007;
^bFujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, State Key Laboratory of Structural Chemistry, Fuzhou, Fujian Province, 350002;
^cFujian College, University of Chinese Academy of Sciences, Fuzhou, Fujian Province, 350002;
^dCollege of Chemistry, Fuzhou University, Fuzhou, Fujian Province, 350108

Received:2026-03-05 Revised:2026-04-18
Contact: *E-mail: hlbao@fjirsm.ac.cn; zhunengbo@fjirsm.ac.cn
Supported by:
National Natural Science Foundation of China (No. 22225107) and the Natural Science Foundation of Fujian Province (No. 2025J01249)

Bidentate phosphine ligands play an important role in catalysis because they can cooperatively regulate the electronic properties and steric environment of transition metal centers. In recent years, significant progress has been made in methods for constructing various diphosphine ligands through the double hydrophosphination (hydrophosphinylation) of alkynes. Considerable advances have been achieved in selectivity control and substrate scope. This review summarizes recent progress in alkyne double hydrophosphination (hydrophosphinylation) from three aspects: transition metal-catalyzed and template-promoted systems, non-transition-metal systems, and radical and photocatalytic systems. The regioselectivity and stereoselectivity in the formation of 1,1- and 1,2-diphosphine frameworks are analyzed. Key issues, such as catalyst deactivation, are also discussed. Finally, the future prospects of this field are outlined.

Key words: Double hydrophosphination, P—C bond formation, bidentate phosphine ligand, selectivity control, catalyst deactivation

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Dongting Cheng, Nengbo Zhu, Hongli Bao. Recent Advances in the Double Hydrophosphination and Hydrophosphinylation of Alkynes[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202603007.

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炔烃双氢膦(酰)化反应的研究进展

Recent Advances in the Double Hydrophosphination and Hydrophosphinylation of Alkynes

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