Visible-Light Promoted Bromotrifluoromethylation Reaction of CF3Br with Unactivated Alkenes

doi:10.6023/cjoc202604019

Abstract

A visible-light promoted bromotrifluoromethylation reaction of CF₃Br with unactivated alkenes was achieved in the presence of catalytic amount of fac-Ir^III(ppy)₃. In the reaction, CF₃Br serves as a bifunctional reagent to provide both the CF₃ group and bromine source. The method features high regioselectivity, mild reaction conditions, high atom economy and good yields, which offers an economical and practical method for the construction of structurally diverse β-trifluoromethylated alkyl bromides.

Key words: visible-light catalysis, CF₃Br, unactivated alkenes, bromotrifluoromethylation, bifunctional trifluoromethylating reagents

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Zhao Mingqi, Huang Danfeng, Wen Huan, Zhang Dan, Wang Ke-Hu, Wang Junjiao, Zhang Bo-Sheng, Hu Yulai. Visible-Light Promoted Bromotrifluoromethylation Reaction of CF₃Br with Unactivated Alkenes[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202604019.

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可见光驱动CF₃Br与未活化烯烃的溴-三氟甲基化反应研究

Visible-Light Promoted Bromotrifluoromethylation Reaction of CF₃Br with Unactivated Alkenes

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可见光驱动CF3Br与未活化烯烃的溴-三氟甲基化反应研究