The α-amido-β-lactams were synthesized via annulatíon of "Dane Salt" with substituted
benzylideneanilines in the presence of ethyl chloroformate and triethylamine. The influence
of substituents of the benzyIideneaniIine on cyclization was studied. The rrelatiòn between
the aromatic substituent constantσand the yields of cyclízation products was estab1ished
by Stepwise Regression Analysís. The yields of cyclization products showed a negative línear
correlation with σbut a positive línear correlation with pK. of azomethines. These properties
might be useful in the prediction of the relative reactivity of cyclization of "Dane Salt" with
azomethines.