Chin. J. Org. Chem. ›› 1990, Vol. 10 ›› Issue (3): 233-236. Previous Articles     Next Articles

Original Articles

2'-脱氧-2'-氟-2'-尿嘧啶-3',4'-0-异亚丙基-L-阿拉伯糖甲苷的合成

马灵台;杨宽斌;董领娇;张礼和   

  1. 北京医科大学药学院
  • 发布日期:1990-06-25

Synthesis of methyl 2'-deoxy-2'-fluoro-2'-uracil-3',4'-O-isopropylidene-L-arabinoside

MA LINGTAI;YANG KUANBIN;DONG LINGJIAO;ZHANG LIHE   

  • Published:1990-06-25

Deoxydifluoropentopyranosides I (R = F) was reacted with trimethylsilylated uracil to give title compounds I (R = uracil) (II). None of these isonucleosides II showed antitumor activity.

Key words: FLUOROURACILUM, ULTRAVIOLET SPECTROPHOTOMETRY, MASS SPECTROGRAPHY, FLUOROHYDROCARBON, NUCLEOSIDE, PROTON MAGNETIC RESONANCE SPECTROMETRY, ISOPROPYL GROUP, F19 NMR SPECTROMETRY, DEOXYRIBONUCLEOSIDES, ARABINOSE

CLC Number: