A new chiral reagent for measuring the enantiomeric purity of chiral acids

Chin. J. Org. Chem. ›› 1990, Vol. 10 ›› Issue (6): 498-503. Previous Articles Next Articles

测定手性有机酸对映体纯度的新试剂

尤田耙;H.S.HOSHER.K.OKAMOTO

中国科学技术大学化学系;斯坦福大学化学系, 加州斯坦福,CA94305,美笯27498-503

发布日期:1990-12-25

A new chiral reagent for measuring the enantiomeric purity of chiral acids

YOU TIANPA;H.S.HOSHER.K.OKAMOTO

Published:1990-12-25

Abstract

A new chiral reagent for measuring the enantiomeric purity of chiral acids was prepared, its absolute configuration was assigned by chem. correlation method. Diastereomeric amides were prepared from this chiral amine and various acids. The NMR spectra of diastereomeric amides show significantly different chem. shifts both in H and F regions. Satisfactory determination of enantiomeric composition of a series of acids was made.

Key words: PHENYLETHYLAMINE P, ORGANIC ACID, PROTON MAGNETIC RESONANCE SPECTROMETRY, METHOXY GROUP, CHEMICAL SHIFT, ENANTIOMORPH, MESOTOMY, F19 NMR SPECTROMETRY, CHIRAL REAGENT, BENZENEETHANEAMINE, FLUOROFORM P

CLC Number:

O621

Cite this article

YOU TIANPA;H.S.HOSHER.K.OKAMOTO. A new chiral reagent for measuring the enantiomeric purity of chiral acids[J]. Chin. J. Org. Chem., 1990, 10(6): 498-503.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

[1]	Cao Chenzhong, Bi Yakun, Cao Chaotun. Effect of Substituents on Reduction Potential of Para-disubstituted N-Benzylidenebenzenamine Derivatives [J]. Chin. J. Org. Chem., 2015, 35(6): 1302-1309.
[2]	LI Wei-Jie*^,1,XU Zun-Le². Synthesis of Multioxazolines in One Step [J]. Chin. J. Org. Chem., 2005, 25(11): 1459-1461.
[3]	LI Wei-Jie, WANG Bo, YAO Jun-Hua, XU Zun-Le. Synthesis of Chiral Oxazolines and Their Applications in Asymmetric ReductiveReaction [J]. Chinese Journal of Organic Chemistry, 2004, 24(10): 1239-1243.
[4]	Li Renyu;Bei Fengli;Wang Jun;Yang Xujie;Xu Xingyou;Lu Lude;Wang Xin. 0108 [J]. Chin. J. Org. Chem., 2003, 23(9): 984-987.
[5]	Chen Lin. Reaction of N-Arylmethylene-2-propenamines with Sodium Methoxide [J]. Chin. J. Org. Chem., 2003, 23(9): 1017-1018.
[6]	Chen Donglin;Li Zhengbang;Peng Chongsheng;Zheng Xizi;Chen Qiaohong;Wang Fengpeng. Full Assignments of ~1H NMR and ~(13)C NMR Spectra of Two Special Skeletal C_(20)-Diterpenoid Alkaloids [J]. Chin. J. Org. Chem., 2003, 23(7): 674-677.
[7]	Qiu Xiyuan. Studies on the Reaction Conditions and Mechanism of Electroorganic Synthesis of 1,4-Bis [ 2- (3,4,5-trimethoxyphenyl) vinyl ] benzene [J]. Chin. J. Org. Chem., 2003, 23(3): 258-264.
[8]	Zhang Anjiang;Zhang Lizue;Hou Yunlong;Xiong Yi. Synthesis and Crystal Structure of Some Dithiocarbohydrazones [J]. Chin. J. Org. Chem., 2003, 23(3): 281-285.
[9]	Peng Huasong;Zong Minhua;Li Ning;Wang Jufang. Synthesis of optically active silicon-containing amino acids [J]. Chin. J. Org. Chem., 2003, 23(2): 115-119.
[10]	Yang Siya;Sun Chengke;Lin Xuefei. Theoretical Study on the Influence of Substituents on Enantioselecthity in Branched-Oxazaborolidine-Catalyzed Reductions of Phenyl-ethyl Ketone [J]. Chin. J. Org. Chem., 2003, 23(12): 1400-1406.
[11]	Zhang Zhanhui;Mo Liping;Liu Qingbin;Li Tongshuang. Preparation and Application in Asymmetrical Synthesis of 2,2'- Diamino-1,1'-binaphthalene [J]. Chin. J. Org. Chem., 2003, 23(1): 37-43.
[12]	Wei Qing;Li Li;Gao Shengli;Guo Feng;Liu Xiaoyu;Shi Qizhen. Synthesis and Structural Characterization of the Complexes of Copper Salts with AMP [J]. Chin. J. Org. Chem., 2003, 23(1): 106-109.
[13]	Su Xianbin;Zhang Qihan;Wu Yongqing;Xu Jiaxi. Preparation of lienar secondary alcohols of high optical purity through chemical resolution with chiral α-phenylethylamines [J]. Chin. J. Org. Chem., 2002, 22(7): 496-500.
[14]	Li Xinsheng;Shen Zongxuan;Zhang Yawen. Hydrolytic kinetic resolution of racemic terminal epoxides catalyzed by co(III)(salen) possessing no C_2-symmetry [J]. Chin. J. Org. Chem., 2002, 22(5): 327-330.
[15]	Luo Yunfu;Li Yuanchao. Asymmetric synthesis of chiral vicinal diol (2s,3r)-1,2,3- butanetriol-1-p-methylbenzensulfonate [J]. Chin. J. Org. Chem., 2002, 22(4): 262-264.

测定手性有机酸对映体纯度的新试剂

A new chiral reagent for measuring the enantiomeric purity of chiral acids

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments