Supramolecular chemistry of peptide bundles

Chin. J. Org. Chem. ›› 1993, Vol. 13 ›› Issue (3): 322-325. Previous Articles Next Articles

Original Articles

肽束的超分子化学

杨念祖

芝加哥大学化学系

发布日期:1993-06-25

Supramolecular chemistry of peptide bundles

YANG NIANZU

Published:1993-06-25

Abstract

Amphiphilic octadecapeptides H-Glu-Gln-Leu-Leu-Lys-Ala-Leu-Glu-X-Leu-Leu-Lys-Glu-Leu-Leu-Glu-Ly s-Leu-OH (X = Phe, Trp) and H-Tyr-Leu-Leu-Glu-Lys-Leu-Leu-Lys-Leu-Leu-Glu-Glu-Leu-Leu-Lys-Gln- Leu-OH, containing 8-9 leucines in the hydrophobic phase, were prepared and shown to self-assoc. to form a-helical bundles. The NMR of the mol. complexes of the peptides and quaternary probe 4-Me(CH2)7OC6H4OCH2CH2NMe3+ I- showed that these hexamers exist as a twisted helix bundle containing and annular space in its middle.

Key words: POLYPEPTIDE, SUPERMOLECULAR CHEMISTRY, LEUCINE

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YANG NIANZU. Supramolecular chemistry of peptide bundles[J]. Chin. J. Org. Chem., 1993, 13(3): 322-325.

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肽束的超分子化学

Supramolecular chemistry of peptide bundles

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