Chin. J. Org. Chem. ›› 1995, Vol. 15 ›› Issue (1): 30-34. Previous Articles     Next Articles

Original Articles

磷酰氨基酸的酯交换反应研究

谭波;赵玉芬   

  1. 清华大学化学系
  • 发布日期:1995-02-25

Ester exchange reaction of phosphoamino acids

TAN BO;ZHAO YUFEN   

  • Published:1995-02-25

In this paper, the relative rate of the ester exchange reaction of the phosphoryl histidine (N-DIPP-His) and other phosphoamino acids with primary alcohols was compared by ^3^!P NMR spectra. It showed that N-DIPP-His was the fastest one. The mechanism was proposed that due to the participation of the imidazole group, the phosphorus could be transformed into a hexa-coordinate transition state which was much favorable for the group exchange reaction.

Key words: TRANSESTERIFICATION, HISTIDINE, PHOSPHORYL COMPOUNDS, TRANSITION STATE, HEXACOORDINATE

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