Resoltion of racemic amine and amino acids by gas chromatography using a new chiral derivatization reagent ----- L-α-trifluoroacetoxy propionyl chloride

Chin. J. Org. Chem. ›› 1995, Vol. 15 ›› Issue (2): 145-149. Previous Articles Next Articles

Original Articles

L-α-三氟乙酰基氧基丙酰基氯对外消旋胺及氨基酸的气相色谱拆分

黄可新;马梅玉;尹承烈

温州医学院化学教研室;北京师范大学化学系

发布日期:1995-04-25

Resoltion of racemic amine and amino acids by gas chromatography using a new chiral derivatization reagent ----- L-α-trifluoroacetoxy propionyl chloride

HUANG KEXIN;MA MEIYU;YIN CHENGLIE

Published:1995-04-25

Abstract

A new chiral reagent L-α-trifluoroacetoxy propionyl chloride was easily synthesised by reactions of L-lactic with trifluoroacetic anhydride and thioryl chloride. Racemic amine and amino acids were resolved by derivatization to their corresponding diastereoisomeric amides with L-α- trifluoroacetoxy propionyl chloride on a capillary column with Carbowax 20 M as the stationary phase of gas chromatography. Under the same conditions, L-amine and L-amino acids were determined. The D-isomers of racemic amine and amino acids were found to have shorter rentention time.

Key words: AMINO ACID, GAS CHROMATOGRAPHY, MESOTOMY, BENZENEETHANEAMINE

CLC Number:

O621

Cite this article

HUANG KEXIN;MA MEIYU;YIN CHENGLIE. Resoltion of racemic amine and amino acids by gas chromatography using a new chiral derivatization reagent ----- L-α-trifluoroacetoxy propionyl chloride[J]. Chin. J. Org. Chem., 1995, 15(2): 145-149.

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L-α-三氟乙酰基氧基丙酰基氯对外消旋胺及氨基酸的气相色谱拆分

Resoltion of racemic amine and amino acids by gas chromatography using a new chiral derivatization reagent ----- L-α-trifluoroacetoxy propionyl chloride

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