Simultaneous synthesis of peptoid containing N-substituted-glycines using the multipin method

Chin. J. Org. Chem. ›› 1996, Vol. 16 ›› Issue (5): 445-449. Previous Articles Next Articles

Original Articles

利用多中心合成方法同步合成含N-取代甘氨酸的类肽化合物

刘刚;王建新;丁振KAI

军事医学科学院毒物药物研究所;CHIRON MIMOTOPES PTY.LTD.

发布日期:1996-10-25

Simultaneous synthesis of peptoid containing N-substituted-glycines using the multipin method

LIU GANG;WANG JIANXIN;DING ZHEN

Published:1996-10-25

Abstract

Peptoid Containing N-Substituted-glycines, or oligo-N-substituted glycines (NSGs) peptide are a new class of polymeric compounds. Compared with peptides, oligo-N-substituted glycines (NSGs) peptide are stable to enzymatic hydrolysis. At the same time, oligo-N-substituted glycines (NSGs) peptide also extended the structural diversities of natural peptides by using a variety of primary amines as building-blocks which are readily available from commercial sources. Here we report that nine oligo-N-substituted glycines (NSGs) peptides were successfully synthesized with the multipin method. Due to their excellent enzyme resistance, these compounds could become useful protease inhibitors.

Key words: GLYCINE, ENZYME INHIBITOR

CLC Number:

O629

Cite this article

LIU GANG;WANG JIANXIN;DING ZHEN. Simultaneous synthesis of peptoid containing N-substituted-glycines using the multipin method[J]. Chin. J. Org. Chem., 1996, 16(5): 445-449.

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利用多中心合成方法同步合成含N-取代甘氨酸的类肽化合物

Simultaneous synthesis of peptoid containing N-substituted-glycines using the multipin method

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