Trace impurities analysis of hydrocortisonum by LC/APCI MS

Chin. J. Org. Chem. ›› 2002, Vol. 22 ›› Issue (2): 123-126. Previous Articles Next Articles

液相色谱/大气压化学电离飞行时间质谱分析氢化可的松中微量杂质

张芳;耿昱;郭寅龙

中国科学院上海有机化学研究所.上海(200032)

发布日期:2002-02-25

Trace impurities analysis of hydrocortisonum by LC/APCI MS

Zhang Fang;Geng Yu;Guo Yinlong

Shanghai Institute of Organic Chemistry.Shanghai(200032)

Published:2002-02-25

Abstract

High performance liquid chromatography-atmosphere pressure chemical ionization time-of-flight mass spectrometry (HPLC-APCI-TOF-MS) has been used for the analysis of impurities in hydrocortisonum. The technique of collision induced dissociation (CID) was applied to identify the structures of the impurities. It was proved to be simple, reliable and repeatable.

Key words: HYDROCORTISONE;HIGH-SPEED LIQUID CHROMATOGRAPHY, ATMOSPHERIC PRESSURE;CHEMICAL IONIZATION SOURCE MASS SPECTROMETRY, TIME-OFF FLIGHT MASS SPECTROMETRY;IMPURITIES;QUALITATIVE ANALYSIS

CLC Number:

O658

Cite this article

Zhang Fang;Geng Yu;Guo Yinlong. Trace impurities analysis of hydrocortisonum by LC/APCI MS[J]. Chin. J. Org. Chem., 2002, 22(2): 123-126.

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液相色谱/大气压化学电离飞行时间质谱分析氢化可的松中微量杂质

Trace impurities analysis of hydrocortisonum by LC/APCI MS

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