Asymmetric Synthesis of 2,4-Dihydroxymethylpyrrolidine Derivatives and Their Inducing Ability for Epoxidation of Olefins

Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (10): 1114-1119. Previous Articles Next Articles

2，4-二羟甲基四氢吡咯衍生物的合成及对烯烃环氧化反应的诱导

郑炎松;江岸

华中科技大学化学系

发布日期:2003-10-25

Asymmetric Synthesis of 2,4-Dihydroxymethylpyrrolidine Derivatives and Their Inducing Ability for Epoxidation of Olefins

Zheng Yansong;Jiang An

Department of Chemistry, Huazhong University of Science and Technology

Published:2003-10-25

Abstract

Chiral 2,4-pyrrolindinediester derivatives were synthesized by asymmetric 1,3-dipolar cycloaddition of imines and menthyl acrylate in the presence of metal ion. Ten new ehiral 2,4- dihydroxymethylpyrrolidine derivatives were prepared by reduction of the 2,4-pyrrolindinediester derivatives with LiAlH_4. The 2,4- dihydroxymethyl-pyrrolidine derivatives were first found to be excellent inducer for epoxidation of olefins with oxone.

Key words: PYRROLE P, EPOXIDATION REACTION, oxone, PROPENOIC ACID ESTER

CLC Number:

O621

Cite this article

Zheng Yansong;Jiang An. Asymmetric Synthesis of 2,4-Dihydroxymethylpyrrolidine Derivatives and Their Inducing Ability for Epoxidation of Olefins[J]. Chin. J. Org. Chem., 2003, 23(10): 1114-1119.

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2，4-二羟甲基四氢吡咯衍生物的合成及对烯烃环氧化反应的诱导

Asymmetric Synthesis of 2,4-Dihydroxymethylpyrrolidine Derivatives and Their Inducing Ability for Epoxidation of Olefins

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