Synthesis of 2,2'-Bipyridine through Catalitic Coupling Reaction of α-Brompyridine Using Nickel Complex

Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (11): 1264-1266. Previous Articles Next Articles

镍络合物催化条件下2,2'-联吡啶的偶联合成

钱延龙;王晨;陶晓春;黄吉玲

华东理工大学金属有机化学研究室

发布日期:2003-11-25

Synthesis of 2,2'-Bipyridine through Catalitic Coupling Reaction of α-Brompyridine Using Nickel Complex

Qian Yanlong;Wang Chen;Tao Xiaochun;Huang Jiling

Laboratory of Orgonometallic Chemistry, East China University of Science and Technology

Published:2003-11-25

Abstract

Ni compounds and PPh3 were usually used in stoichiometric amounts for the synthesis of bipyridine via coupling reaction. This reaction procedure was improved by using only catalytical amounts of nickel and PPh3 in the presence of zinc. This modification was mainly based on the changes of reaction addition order which could sufficiently utilize the Ni(0) generated in situ. Bipyridine can be synthesized by this catalytical procedure with satisfactory yield. The activity of three kinds of Ni complexes was compared in the reaction, and NiCl_2· 6H_2O represented the highest activity.

Key words: PYRIDINE P;BIPYRIDINE;COUPLED;CATALYTIC REACTION;NICKEL COMPOUNDS, CATALYTIC ACTIVITY

CLC Number:

O621

Cite this article

Qian Yanlong;Wang Chen;Tao Xiaochun;Huang Jiling. Synthesis of 2,2'-Bipyridine through Catalitic Coupling Reaction of α-Brompyridine Using Nickel Complex[J]. Chin. J. Org. Chem., 2003, 23(11): 1264-1266.

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镍络合物催化条件下2,2'-联吡啶的偶联合成

Synthesis of 2,2'-Bipyridine through Catalitic Coupling Reaction of α-Brompyridine Using Nickel Complex

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