Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (4): 344-349. Previous Articles     Next Articles

二烃基锡二茂铁羧酸酯的合成及研究

彭斌;孙丽娟;常卫星;谢庆兰   

  1. 南开大学
  • 发布日期:2003-04-25

Syntheses and Study of Diorganotin Ferrocenoates

Peng Bin;Sun LiJuan;Chang WeiXing;Xie QinLan   

  1. National Key Laboratory of Elemento-Organic Chemistry, Nankai University
  • Published:2003-04-25

Fourteen new diorganotin carboxylates were synthesized by the condensation of diorganotin oxide and substituted-ferrocenyl carboxylic acid. The structures of the products were determined by H NMR, IR and elemental analysis. The struture of compound 12 was determined by X-ray crystallography analysis. The molecule is centrosymmetric dimer and has a core of Sn-2O-2 unit. The endocyclic Sn atoms exist in a distorted triginal bipyramidal geometry with the coordination number of 5. The exocyclic Sn atoms form 6 significant bonds and exist in a distorted octahedron geometry. The results of antitumor tests showed that some of the products have high inhibiting activity for KB ceUs and Bel-7402 cells.

Key words: ORGANO TIN COMPOUNDS;CARBOXYLIC ACID ESTER;FERROCENE;CONDENSATION REACTION, NMR;IR;ELEMENTAL ANALYSIS;ANTICARCINOGEN

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