Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (4): 387-389. Previous Articles     Next Articles

手性氨基酚催化二乙基锌对芳香醛的不对称加成反应

李新生;沈宗旋;葛健锋;张雅文   

  1. 苏州大学化学化工系
  • 发布日期:2003-04-25

Enantioselective Addition of Diethylzinc to Aromatic Aldehydes with Aminohenol as Catalysts

Li XinSheng;Shen ZongXuan;Ge JianFeng;Zhang YaWen   

  1. Department of Chemistry and Chemical Engineeing,Suzhou University
  • Published:2003-04-25

Four aminophenols have been prepared and evaluated as the catalysts for the enantioselective addition of diethylzinc to aromatic aldehydes. ligand la was found to show the best asymmetric induction in the catalysis of the reaction of m-chlorobenzaldehyde to provide sec- alcohol with high yield (95%) and moderate ee (57%).

Key words: AMINOPHENOL;ZINC COMPOUNDS;aromatic aldehyde;ASYMMETRICAL SYNTHESIS, ADDITION REACTION;CATALYTIC REACTION

CLC Number: