Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (5): 475-478. Previous Articles     Next Articles

二{氧合-二[2-呋喃甲酸二苄基锡(IV)]}的合成、性质及晶体结构

尹汉东;王传华;马春林   

  1. 聊城大学化学系
  • 发布日期:2003-05-25

Synthesis, Anti-tumour Properties and Crystal Structure of Bis { oxo-bis[ (2-furylcarboxylato)dibenzyltin(IV) ]}

Yin Handong;Wang Chuanhua;Ma Chunlin   

  1. Department of Chemistry,Liaocheng University
  • Published:2003-05-25

Bis { oxo-bis [ (2-furylcarboxylato ) dibenzyltin (IV) ] } was synthesized by the reaction of 2-furylcarboxylic acid with the (PhCH2) 2SnO. The compound was tested against two human tumour cell lines: MCF- 7 and WiDr. The results showed that this compound had higher activities in vitro. The crystal structure was determined by X-ray diffraction study. The compound possesses centrosymmetric dimer structure mode with a four-member central endo-cyclic Sn2O2 unit in which the bridged oxygen atoms are tri-coordinated. Each bridged oxygen atom also connects with an era-cyclic tin atom. The endo-cyc\ic tin atoms are six-coordination and have coordination geometry of distorted octahedron. The ew-cyclic tin atoms are five-coordinate and have coordination geometry of monocapped trigonal bipyramid with very similarly distorted mode.

Key words: CRYSTAL STRUCTURE;FURANCARBOXYLIC ACID P;ORGANO TIN COMPOUNDS, ANTICARCINOGEN;BIOLOGICAL ACTIVITY

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