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Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (5): 475-478. Previous Articles Next Articles
尹汉东;王传华;马春林
发布日期:
Yin Handong;Wang Chuanhua;Ma Chunlin
Published:
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Bis { oxo-bis [ (2-furylcarboxylato ) dibenzyltin (IV) ] } was synthesized by the reaction of 2-furylcarboxylic acid with the (PhCH2) 2SnO. The compound was tested against two human tumour cell lines: MCF- 7 and WiDr. The results showed that this compound had higher activities in vitro. The crystal structure was determined by X-ray diffraction study. The compound possesses centrosymmetric dimer structure mode with a four-member central endo-cyclic Sn2O2 unit in which the bridged oxygen atoms are tri-coordinated. Each bridged oxygen atom also connects with an era-cyclic tin atom. The endo-cyc\ic tin atoms are six-coordination and have coordination geometry of distorted octahedron. The ew-cyclic tin atoms are five-coordinate and have coordination geometry of monocapped trigonal bipyramid with very similarly distorted mode.
Key words: CRYSTAL STRUCTURE;FURANCARBOXYLIC ACID P;ORGANO TIN COMPOUNDS, ANTICARCINOGEN;BIOLOGICAL ACTIVITY
CLC Number:
R914
Yin Handong;Wang Chuanhua;Ma Chunlin. Synthesis, Anti-tumour Properties and Crystal Structure of Bis { oxo-bis[ (2-furylcarboxylato)dibenzyltin(IV) ]}[J]. Chin. J. Org. Chem., 2003, 23(5): 475-478.
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