Synthesis and Characterization of Dimer-VB_(12) Model Molecules

Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (8): 799-803. Previous Articles Next Articles

双分子维生素B_(12)模型分子的合成及表征

冯亚青;张晓东;孟舒献;张卫红

天津大学化工学院精细化工系

发布日期:2003-08-25

Synthesis and Characterization of Dimer-VB_(12) Model Molecules

Feng Yaqing;Zhang Xiaodong;Meng Shuxian;Zhang Weihong

Department of Fine Chemicals, School of Chemical Engineering and Technology; State Key Laboratory for Cl Chemical Technology, Tianjing University

Published:2003-08-25

Abstract

The starting compound hexamethylcobyrinate (1) obtained by alcoholysis of vitamin B12 was hydrolysed in acid media to give b, c, d, e, f-mono acid cobyrinates 2b ~ 2f. 2b ~ 2f reacted with 3- imidazolyl-propylamine hydrochloride to give amido cobyrinate derivatives 3b ~ 3f. Dimer-vitamin Bjj model molecules, dimer-cyano- hexamethyl-Af-(3-imidazolyl)propylamido cobyrinate perchlorates 5b ~ 5f were synthesized from 3b ~ 3f in the presence of acetic acid. The structures of 5b ~ 5f were characterized.

Key words: VB12;ALCOHOLYSIS;PROPANAMIDE P;COBALT COMPOUNDS;STRUCTURE CHARACTERISTICS, PERCHLORATE

CLC Number:

O621

Cite this article

Feng Yaqing;Zhang Xiaodong;Meng Shuxian;Zhang Weihong. Synthesis and Characterization of Dimer-VB_(12) Model Molecules[J]. Chin. J. Org. Chem., 2003, 23(8): 799-803.

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双分子维生素B_(12)模型分子的合成及表征

Synthesis and Characterization of Dimer-VB_(12) Model Molecules

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