Synthesis of Chroman-4-ono[2,3-b]quinolinone Derivatives

Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (9): 1004-1007. Previous Articles Next Articles

色满-4-酮并[2,3-b]喹啉酮衍生物的合成

韩光范;王进军;姜贵吉

华东船舶工业学院材料科学与工程学院;烟台大学应用化学系;延边大学化学系

发布日期:2003-09-25

Synthesis of Chroman-4-ono[2,3-b]quinolinone Derivatives

Han Guangfan;Wang Jinjun;Jiang Guiji

School of Materials Science and Engineering, East China Shipbuilding Institute;Department of Applied Chemistry, Yantai University;Department of Chemistry, Yanbian University

Published:2003-09-25

Abstract

New building block 5-aryl-l, 3-cyclohexanediones were obtained by reaction of acetone with the appropriate aromatic aldehydes, and sequently with diethyl malonate. 5-Aryl-l, 3-cyclohexanedione and 2- amino-3-formyl-4-chromanone were condensed by utilizing Friedlaender synthetic method to obtain the title compounds. Title compounds were a new form of tetracyclic system. The preliminary in vitro pharmacodynamic experiments show that compound 2a possesses a significant inhibition effect on the growth of tumours cell.

Key words: QUINOLINONE P;CYCLOHEXANEDIONE;ANTICARCINOGEN;1HNMR;C13NMR, IR;ELEMENTAL ANALYSIS;PHARMACOLOGY

CLC Number:

O621

Cite this article

Han Guangfan;Wang Jinjun;Jiang Guiji. Synthesis of Chroman-4-ono[2,3-b]quinolinone Derivatives[J]. Chin. J. Org. Chem., 2003, 23(9): 1004-1007.

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色满-4-酮并[2,3-b]喹啉酮衍生物的合成

Synthesis of Chroman-4-ono[2,3-b]quinolinone Derivatives

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