Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (1): 88-92. Previous Articles     Next Articles

磷脂核苷缀合物甘油结构修饰新方法及应用

周冰a, 许新华*,a,b, 张秋林a, 陈茹玉b   

  1. a湖南大学化学化工学院 化学生物传感与计量学国家重点实验室 长沙 410082;
    b南开大学元素有机化学国家重点实验室 天津 300071
  • 收稿日期:2002-12-27 接受日期:2003-07-14 发布日期:2022-09-21
  • 基金资助:
    国家自然科学基金(No. 20372020)、教育部高等学校重点实验室访问学者基金资助项目.

A New Efficient Method for the Modification of Glycerin Skeleton in Phospholipid-nucleoside Conjugate and Its Application

ZHOU Binga, XU Xin-Hua*,a,b, ZHANG Qiu-Lina, CHEN Ru-Yub   

  1. aState Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering,Hunan University, Changsha 410082;
    bState Key Laboratory of Elemento-Organic Chemistry, Nankai University,Tianjin 300071
  • Received:2002-12-27 Accepted:2003-07-14 Published:2022-09-21
  • Contact: *E-mail: xhx1581@21cn.com

Nucleophilic ring opening of cyclic glycerothiophospholipid-nucleoside conjugate provides a simple and efficient path for the modification of glycerin skeleton. The ring opening can be accomplished by triethylamine at room temperature togave a novel phosphocholine analogs containing nucleosides.

Key words: nucleoside, glycerothiophospholipid-nucleoside conjugate, nucleophilic ring opening, modification of glycerin skeleton