Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (12): 1640-1643. Previous Articles    

表皮生长因子受体的ATP竞争性抑制剂

蒋毅, 郭宗儒*   

  1. 中国医学科学院中国协和医科大学药物研究所 北京 100050
  • 收稿日期:2003-09-08 修回日期:2004-03-08 接受日期:2004-06-11 发布日期:2022-09-20
  • 基金资助:
    国家科委863计划(No. 2002AA2Z3118)资助项目

ATP Competitive Inhibitors of Epidermal Growth Factor Receptor

JIANG Yi, GUO Zong-Ru*   

  1. Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking UnionMedical College, Beijing 100050
  • Received:2003-09-08 Revised:2004-03-08 Accepted:2004-06-11 Published:2022-09-20
  • Contact: *E-mail: jsnjcpuwubin@163.com

This article reviews the recent research progress in ATP competitive inhibitorsof epidermal growth factor receptor. The binding manner and inhibiting mechanismare introduced, with an emphasis on the mechanism and structure-activity relationship of both reversible and irreversible inhibitors.

Key words: epidermal growth factor receptor, EGFR, ATPcompetitive inhibitor, reversible inhibitor, irreversible inhibitor