Eight 2,4-diaryl-1,3-dioxolane, -1,3-dithiolane and 2,5-diaryl-1,3-oxothiolane amino compounds were synthesized, which were then acylated through seratrodast (SD), a thromboxane A₂ receptor-antagonist, to givetarget compounds I₁～I₈, and their structures were confirmed by IR, ¹H NMR,MS and elemental analysis. The existence and ratio of cis- to trans-isomers were identified by ¹H NMR. Preliminary pharmacological test showedthat most of these target compounds exhibited potent antiasthmatic activities, among which I₁ and I₂ were more active than control SD.

Key words: thromboxane A₂ receptor-antagonist, seratrodast,synthesis, antiasthmatic activity