Synthesis and Biological Activity of α-(1,3,4-Thiadiazol-5-yl)-aminoalkyl Phosphonates

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (08): 1007-1010. Previous Articles Next Articles

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α-(1,3,4-噻二唑-5-基)氨基烃基膦酸酯的合成及生物活性

曹蕾，汪焱钢*，宋新建，刘国华

(¹华中师范大学化学学院武汉 430079)
(²深圳市水质检测中心深圳 518036)

收稿日期:2004-10-25 修回日期:2005-02-28 发布日期:2005-07-30
通讯作者: 汪焱钢

Synthesis and Biological Activity of α-(1,3,4-Thiadiazol-5-yl)-aminoalkyl Phosphonates

CAO Lei,WANG Yan-Gang*,SONG Xin-Jian,LIU Guo-Hua

(¹ College of Chemistry, Central China Normal University, Wuhan 430079)
(² Shenzhen Water Quality Centre, Shenzhen 518036)

Received:2004-10-25 Revised:2005-02-28 Published:2005-07-30
Contact: WANG Yan-Gang

Abstract

Fifteen new α-(1,3,4-thiadiazol-5-yl)aminoalkyl phosphonates have been synthesized by addition reaction of diethyl phosphite to the corresponding Schiff bases of 5-amino-2-mecapto-1,3,4-thiadiazole. Preliminarily biological activity tests show that some target compounds have good activity as plant growth regulator, particularly α-aminoalkyl phosphonates of 2,4-dichlorobenzaldehyde, furfuraldehyde and indolylaldehyde have better auxin activity.

Key words: thiadiazole, phosphonate, auxin, plant growth regulator, biological activity, Schiff base

Cite this article

CAO Lei,WANG Yan-Gang*,SONG Xin-Jian,LIU Guo-Hua. Synthesis and Biological Activity of α-(1,3,4-Thiadiazol-5-yl)-aminoalkyl Phosphonates[J]. Chin. J. Org. Chem., 2005, 25(08): 1007-1010.

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α-(1,3,4-噻二唑-5-基)氨基烃基膦酸酯的合成及生物活性

Synthesis and Biological Activity of α-(1,3,4-Thiadiazol-5-yl)-aminoalkyl Phosphonates

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