Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (02): 211-214. Previous Articles     Next Articles

Original Articles

磺氨基醇手性配体的合成及钛配合物催化二乙基锌对醛的不对称加成反应

惠新平*,乔仁忠,许鹏飞   

  1. (兰州大学功能有机分子化学国家重点实验室 兰州 730000)
  • 收稿日期:2005-02-05 修回日期:2005-08-29 发布日期:2006-01-21
  • 通讯作者: 惠新平

Synthesis of Sulfonylated Amino Alcohols and Asymmetric Addition of Diethylzinc to Aldehydes Catalyzed by Titanium Complexes

HUI Xin-Ping*,QIAO Ren-Zhong,XU Peng-Fei   

  1. (State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000)
  • Received:2005-02-05 Revised:2005-08-29 Published:2006-01-21
  • Contact: HUI Xin-Ping

Sulfonylated amino alcohols 35 were prepared and the asymmetric addition of di-ethylzinc to aldehydes catalyzed by titanium complexes of those ligands was carried out. Good enantiose-lectivities were obtained with ee values up to 91%.

Key words: (+)-10-camphorsulfonyl chloride, sulfonylated amino alcohol, diethylzinc, Ti(O-i-Pr)4