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Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (04): 508-513. Previous Articles Next Articles
Original Articles
唐洁,石鸿昌*,张治国,王歆燕
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TANG Jie,SHI Hong-Chang*,ZHANG Zhi-Guo,WANG Xin-Yan
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In this paper, chiral molybdenum(VI) or tungsten(VI) 2'-pyridinyl alcoholate complex catalyzed asymmetric epoxidation of cis-1-propenylphosphonic acid in H2O was reported. This is an asymmetric epoxidation reaction taking place on the solid-liquid interface. The highest ee value of 71% was achieved by using chiral molybdenum(VI) 2'-pyridingyl alcoholate complex at 0 ℃. After addition of phase transfer catalyst Bu4NBr, the yield and ee value were remarkably increased. For example, using chiral tungsten(VI) 2'-pyridinyl alcoholate complex at 50 ℃, the ee value was increased from 54% to 78%.
Key words: cis-1-propenylphosphonic acid, heterogeneous catalytic reaction, fosfomycin, chiral 2'-pyridinyl alcoholate complex, catalytic asymmetric epoxidation
TANG Jie,SHI Hong-Chang*,ZHANG Zhi-Guo,WANG Xin-Yan. Heterogeneous Asymmetric Epoxidation of cis-1-Propenyl-phosphonic Acid in H2O Catalyzed by Chiral Mo(VI) or W(VI) 2'-Pyridinyl Alcoholate Complex[J]. Chin. J. Org. Chem., 2006, 26(04): 508-513.
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