Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (11): 1548-1552. Previous Articles     Next Articles

Original Articles

1-取代异喹啉合成新方法的研究

陈国英,卢胜梅,周永贵*   

  1. (中国科学院大连化学物理研究所 大连 116023)
  • 收稿日期:2006-02-14 修回日期:1900-01-01 发布日期:2006-10-27
  • 通讯作者: 周永贵

A New Synthetic Method of 1-Substituted Isoquinolines

CHEN Guo-Ying,LU Sheng-Mei,ZHOU Yong-Gui*   

  1. (Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023)
  • Received:2006-02-14 Revised:1900-01-01 Published:2006-10-27
  • Contact: ZHOU Yong-Gui

A series of 1-substituted isoquinolines were synthesized through the nucleophilic addition reaction of Grignard reagents to isoquinolines under the activation of benzyl chloroformate and aromatization in the presence of Pd/C.

Key words: Pd/C, aromatization, nucleophilic addition