The starting material L-α-amino acids were converted into N-p-toluenesulfonyl-L-α-amino acid hydrazides 2 through following steps, esterification, amino protection and hydrazinolysis. The reaction of 2 with glycosyl isothio-cyanates 3～5 gave the novel compounds, N-glycosyl-N'-amido thioureas 6～8. The compounds 6～8 were cyclized under the system of Hg(OAc)₂/EtOH to afford a series of new compounds, 2- p-toluenesulfonylaminoalkyl-5-glycosylamino-1,3,4-oxadiazoles 9～11. The structures of the new compounds were confirmed by IR, ¹H NMR, MS spectra and elemental analysis.

Key words: amino acid hydrazide, 1,3,4-oxadiazole, glycosyl isothiocyanate, amido thiourea, L-α-amino acid