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Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (06): 768-771. Previous Articles Next Articles
Original Articles
徐刚,孙丰来,吴坚平,杨立荣*
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XU Gang, SUN Feng-Lai, WU Jian-Ping, YANG Li-Rong*
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A new way to synthesis of (S)-tert-butyl 6-benzyloxy-5-hydroxy-3-oxohexanoate was investigated. The target compound was successfully prepared via several mildly reaction processes by using R-epichlorohydrin, which is an inexpensive and easily available starting material. Through screening the amounts of BF3•Et2O and comparing two different synthetic methods, this route becomes more suitable for large-scale preparation for its high yields, mildly reacting-conditions, easily available materials and facilely purification of products.
Key words: R-epichlorohydrin, (S)-1-benzyloxy-2,3-epoxypropane, (R)-3-chloro-1- benzyloxy-2-propanol, (S)-4-benzyloxy-3-hydroxybutanenitrile, (S)-tert-butyl 6-benzyloxy-5-hydroxy-3-oxohexanoate
XU Gang, SUN Feng-Lai, WU Jian-Ping, YANG Li-Rong*. A New Way to Synthesis of (S)-tert-Butyl 6-Benzyloxy-5-hydroxy-3-oxohexanoate[J]. Chin. J. Org. Chem., 2007, 27(06): 768-771.
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