Synthesis and Characterization of Glycidyl Ether Modified β-Cyclodextrin Derivatives

Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (08): 1022-1026. Previous Articles Next Articles

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系列缩水甘油醚类β-环糊精衍生物的合成及结构表征

张毅民*，陈春凤，孙聪善，李潇

(天津大学化工学院绿色合成与转化教育部重点实验室天津300072)

收稿日期:2006-09-26 修回日期:1900-01-01 发布日期:2007-07-30
通讯作者: 张毅民*

Synthesis and Characterization of Glycidyl Ether Modified β-Cyclodextrin Derivatives

ZHANG Yi-Min*, CHEN Chun-Feng, SUN Cong-Shan, LI Xiao

(Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072)

Received:2006-09-26 Revised:1900-01-01 Published:2007-07-30
Contact: ZHANG Yi-Min*

Abstract

Using phenyl glycidyl ether (1), 2-methylphenyl glycidyl ether (2), benzyl glycidyl ether (3) and β-cyclodextrin as raw materials, in 1.5% (m/V) and 30% (m/V) sodium hydroxide solution, novel β-cyclodextrin derivatives have been synthesized. The products were isolated by using proper eluent V(1-propanol)∶V(water)∶V(concd aq ammonia)＝6∶3∶1 through a self packed silica gel column chro-matography, and their chemical structures were proved to be mono 2-substituted phenoxy (or 2-methylphenoxy or benzyloxy)-2-hydroxypropyl-β-cyclodextrin (1a～3a) and mono 6-substituted phenoxy (or 2-methylphenoxy)-2-hydroxypropyl-β-cyclodextrin (1b～2b) by means of TLC, IR, MS, ¹H NMR and ¹³C NMR spectra.

Key words: mass spectrometry, glycidyl ether, nuclear magnetic resonance spectroscopy, thin-layer chromatography (TLC), β-cyclodextrin

Cite this article

ZHANG Yi-Min*, CHEN Chun-Feng, SUN Cong-Shan, LI Xiao. Synthesis and Characterization of Glycidyl Ether Modified β-Cyclodextrin Derivatives[J]. Chin. J. Org. Chem., 2007, 27(08): 1022-1026.

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系列缩水甘油醚类β-环糊精衍生物的合成及结构表征

Synthesis and Characterization of Glycidyl Ether Modified β-Cyclodextrin Derivatives

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