A convenient and efficient procedure is described for the preparation of β-elemene-13-yl alkyl selenides by treatment of selenium with N2H4•H2O/RX/NaBH4/13-chloro-β-elemene sequentially in one-pot at room temperature. This method has several advantages such as simple operation, short reaction time, mild conditions and high yields. It also provides a convenient and efficient way to the synthesis of unsymmetrical dialkyl selenides. The preliminary bioassay showed that product g exhibited notable antioxidation activity.

Key words: β-elemene, one-pot procedure, antioxidation, unsymmetrical selenide