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Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (08): 1439-1444. Previous Articles Next Articles
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马大友
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MA, Da-You
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Rhodococcus erythropolis AJ270, a nitrile hydratase/amidase-containing microbial whole-cell catalyst, is able to catalyze the hydrolysis of a number of β-amino-β-phenyl-propionitrile derivatives under very mild conditions to produce the corresponding β-amino acids and β-amino acid amides. Both the efficiency and enantioselectivity of biocatalysis, however, were strongly dependent upon the structures of both nitrile and amide substrates. While biotransformations of racemic 3-amino-3-phenylpropionitrile gave low enantioselectivity, their N-methylated derivatives underwent moderate enantioselective biocatalytic reactions to afford the corresponding S-β-amino acids and R-β-amino acid amides. N-Bulky group substitution dra-matically slowed down the biotransformations.
Key words: nitrile hydratase, β-amino acid amide, amidase, β-amino acid, enantioselective biotransformation
MA, Da-You. Nitrile Biotransformations for Asymmetric Synthesis of β-Amino Acid and β-Amino Acid Amide[J]. Chin. J. Org. Chem., 2008, 28(08): 1439-1444.
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