To optimize the biomedical application of aliphatic polyester and polyphosphoester, a series of copolymers containing aliphatic polyester and polyphosphoester segments in the repeat units were synthesized via con-densation polymerization reaction with adipoyl chloride, ethyl dicholorophosphate and triethylene glycol as the beginning materials. The effects of reaction conditions on polymerization were studied and the structures of final polymers were characterized by 1H NMR, FT-IR and MALDI-TOF MS. Dynamic contact angle was used to characterize the surface capability of the polymers. The controlled release character of the copolymers was studied by a fluorescence method using neutral red as a model drug.

Key words: polyphosphoester, aliphatic polyester, dynamic contact angle, drug release, neutral red