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Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (02): 159-165. Previous Articles     Next Articles

Review

磷酸二酯酶2 (PDE2)结构及其选择性抑制剂的研究进展

赵新筠; 陈 喜; 湛昌国*   

  1. (a华中师范大学化学学院 农药与化学生物学教育部重点实验室 武汉 430079)
    (b Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky,
    725 Rose Street, Lexington, KY 40536, USA)
  • 收稿日期:2007-12-16 修回日期:2008-06-15 发布日期:2009-02-20
  • 通讯作者: 湛昌国

Advances in the Structure of Phosphodiesterase 2 and Selective Inhibitors

Zhao, Xinyun; Chen, Xi ; Zhan, Changguo*   

  1. (a Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry,
    Central China Normal University, Wuhan, 430079 China)
    (b Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street,
    Lexington, KY 40536, USA)
  • Received:2007-12-16 Revised:2008-06-15 Published:2009-02-20
  • Contact: Zhan, Changguo

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Phosphodiesterase 2 (PDE2) is mainly distributed in brain and heart cells. PDE2 is a potential drug target that plays an important role to maintain the level of intracellular second messengers cAMP and cGMP through PDE2-catalyzed hydrolysis of cAMP and cGMP. Selective inhibitors of PDE2 are expected to be valuable in improving permeability of endothelial cells and memory. In this article, the physiological function, distribution, and characteristics of the regulatory and catalytic domains, as well as some selective inhibitors against PDE2 are reviewed. Finally, based on the trend of the drug design, future design of PDE2 inhibitors is also prospected.