A new series of (1S,2S,3S,5R)-N-alkyl-3-pinanamines were synthesized from (1S,5S)-(－)- α-pinene. (1S,2S,5R)-(－)-3-pinanone was obtainted from (－)-α-pinene by hydroboration and oxidation with pyridinium dichromate (PDC), and then it was reacted with alkylamines under catalysis of boron trifluoride-diethyl etherate to afford Schiff bases, which were further reduced with KBH4 or NaBH4 to get (1S,2S,3S,5R)-N-alkyl-3-pinanamines. The structures of (1S,2S,5R)-N-alkyl-3-pinanimines and (1S,2S,3S, 5R)-N-alkyl-3-pinanamines were determined by FT-IR, 1H NMR, 13C NMR and GC-MS techniques. Anti-bacterial and antifungal tests of the synthesized N-alkyl-3-pinanamines were also carried out and it has been observed that (1S,2S,3S,5R)-N-(n-heptyl)-3-pinanamine was a more potent bactericide and fungicide than others, which has good activities against bacteria and fungi.

Key words: bacteriostatic activity, (1S,2S,5R)-N-alkyl-3-pinanimine, (1S,2S,5R)-(－)-3-pin- anone, (1S,2S,3S,5R)-N-alkyl-3-pinanamine