Research Progress in HIV Integrase Inhibitors

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (04): 477-485. Next Articles

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HIV整合酶抑制剂的研究进展

郭涤亮¹^{,2，刘冠男¹，周宇¹，李建¹，徐进宜²，蒋华良¹，陈凯先¹，柳红*^,1,2}

(¹中国科学院上海药物研究所新药研究国家重点实验室药物设计和发现中心上海 201203)
(²中国药科大学药学院南京210009)

收稿日期:2009-04-16 修回日期:2009-08-06 发布日期:2010-04-28
通讯作者: 柳红 E-mail:hliu@mail.shcnc.ac.cn
基金资助:
国家级.863计划

Research Progress in HIV Integrase Inhibitors

Guo Diliang¹^,2 Liu Guannan¹ Zhou Yu^1,Li Jian¹ Xu Jinyi² Jiang Hualiang¹ Chen Kaixian¹ Liu Hong*^,1,2

(¹Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203)
(²School of Pharmacy, China Pharmaceutical University, Nanjing 210009)

Received:2009-04-16 Revised:2009-08-06 Published:2010-04-28
Contact: Hong Liu E-mail:hliu@mail.shcnc.ac.cn

Abstract

HIV integrase is one of the three essential enzymes for viral DNA replication and the molecular target of the newly approved anti-AIDS drug raltegravir (MK-0518, Isentress). HIV integrase inhibitors have emerged as a new class of drugs for the treatment of AIDS. In this article, the recent progress of HIV integrase inhibitors is reviewed to provide some useful information for the further research and development of HIV integrase inhibitors.

Key words: HIV, integrase inhibitor, diketoacid, Raltegravir

Cite this article

GUO Di-Liang, LIU Guan-Nan, ZHOU Yu, LI Jian, XU Jin-Yi, JIANG Hua-Liang, CHEN Kai-Xian, LIU Gong. Research Progress in HIV Integrase Inhibitors[J]. Chin. J. Org. Chem., 2010, 30(04): 477-485.

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HIV整合酶抑制剂的研究进展

Research Progress in HIV Integrase Inhibitors

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