Synthesis and Cleavage Properties for DNA of A Novel Porphyrin- Anthraquinone Hybrid with Dipeptide Link and Its Metal Complex

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (11): 1677-1681. Previous Articles Next Articles

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二肽链键联的卟啉-蒽醌化合物及其金属配合物的合成及其对 DNA断裂的性质研究

陈年友*^{,1，程水明²，赵胜芳¹，董甲庆³，龚平秀¹，汪思迪²，李早英³}

(¹黄冈师范学院化学与应用化学学院黄冈 438000)
(²黄冈师范学院生命科学与工程学院黄冈 438000)
(³武汉大学化学与分子科学学院武汉 430072)

收稿日期:2009-09-27 修回日期:2010-02-08 发布日期:2010-06-10
通讯作者: 陈年友 E-mail:chennyou@126.com;chennyou@hgnu.edu.cn;chennyou@hgpu.edu.cn
基金资助:
湖北省自然科学基金(2007ABA064);湖北省教育厅重大科研项目基金(No.Z200727001)

Synthesis and Cleavage Properties for DNA of A Novel Porphyrin- Anthraquinone Hybrid with Dipeptide Link and Its Metal Complex

Chen Nianyou*^{,1 Cheng Shuiming² Zhao Sheng-fang¹ Dong Jiaqing³ Gong Pingxiu¹ Wang Sidi² Li Zaoying³}

(¹ College of Chemical and Applied Chemistry, Huanggang Normal University, Huanggang 438000)
(² College of Life Science and Engineering, Huanggang Normal University, Huanggang 438000)
(³ College of Chemistry and Molecular Sciences, Wuhan Univer-sity, Wuhan 430072)

Received:2009-09-27 Revised:2010-02-08 Published:2010-06-10
Contact: Nian-you CHEN E-mail:chennyou@126.com;chennyou@hgnu.edu.cn;chennyou@hgpu.edu.cn

Abstract

A novel porphyrin-anthraquinone (Por-AQ) hybrid dipeptide link and its zinc complex have been synthesized on the microwave radiation, and their structures were characterized by UV-Vis, IR and ¹H NMR spectra. Using the electrophoresis experiment, the binding properties of the hybrids to PET28a DNA have been investigated. The experimental results show that target compounds have cleavage properties for PET28a DNA.

Key words: porphyrin-anthraquinone, metal porphyrin, microwave synthesis, spectral characterization, DNA cleavage

CLC Number:

O625.13

Cite this article

CHEN Nian-You, CHENG Shui-Ming, ZHAO Sheng-Fang, DONG Jia-Qing, GONG Ping-Xiu, WANG Si-Di, LI Zao-Ying. Synthesis and Cleavage Properties for DNA of A Novel Porphyrin- Anthraquinone Hybrid with Dipeptide Link and Its Metal Complex[J]. Chin. J. Org. Chem., 2010, 30(11): 1677-1681.

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二肽链键联的卟啉-蒽醌化合物及其金属配合物的合成及其对 DNA断裂的性质研究

Synthesis and Cleavage Properties for DNA of A Novel Porphyrin- Anthraquinone Hybrid with Dipeptide Link and Its Metal Complex

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