Synthesis and Herbicidal Activity of 5-Arylmethoxy Phenylpyrazole Derivatives

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (07): 1020-1026. Previous Articles Next Articles

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5-芳甲氧基苯基吡唑衍生物的合成及除草活性

董晓亮，周宇涵*，徐珊珊，曲景平*

(大连理工大学制药科学与技术学院精细化工国家重点实验室大连 116012)

收稿日期:2010-10-30 修回日期:2011-01-04 发布日期:2011-02-17
通讯作者: 周宇涵 E-mail:zhouyh@dl.cn

Synthesis and Herbicidal Activity of 5-Arylmethoxy Phenylpyrazole Derivatives

DONG Xiao-Liang, ZHOU Yu-Han, XU Shan-Shan, QU Jing-Ping

(State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian Uni-versity of Technology, Dalian 116012)

Received:2010-10-30 Revised:2011-01-04 Published:2011-02-17
Contact: Yu-Han ZHOU E-mail:zhouyh@dl.cn

A series of novel 5-arylmethoxy phenylpyrazole derivateves are prepared from 4-chloro-2- fluoro-5-methoxybenzaldehyde via a condensation, ring closure, methylation, etc. All these structures are identified by ¹H NMR and HRMS techniques. Preliminary bioassay shows that some of the title compounds exhibit good herbicidal activity against the weeds. Especially, 4-cholro-3-[4-chloro-2-fluoro-5-(4-methoxy- benzy-loxy)phenyl]-1-methyl-5-trifluoromethyl)-1H-pyrazole shows 95% inhibition to abutilon at the dos-age of 9.375 g•hm^－2.

Key words: herbicide, protoporphyrinogen oxidase inhibitor, pyrazole derivative

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DONG Xiao-Liang, ZHOU Yu-Han, XU Shan-Shan, QU Jing-Ping. Synthesis and Herbicidal Activity of 5-Arylmethoxy Phenylpyrazole Derivatives[J]. Chin. J. Org. Chem., 2011, 31(07): 1020-1026.

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5-芳甲氧基苯基吡唑衍生物的合成及除草活性

Synthesis and Herbicidal Activity of 5-Arylmethoxy Phenylpyrazole Derivatives

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