Synthesis and Fungicidal Activities of Aryl Thiocarbamic Acid-5-aryl-2-furanmethyl Ester

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (9): 1411-1418. Previous Articles Next Articles

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取代苯甲酰胺基硫代甲酸-(5-取代苯基-2-呋喃)-甲酯的合成及杀菌活性

李映^1,3，李宝聚²，杨新玲¹，石延霞²，苗宏健¹，凌云*^,1

(¹中国农业大学理学院应用化学系农业部农药化学及应用重点开放实验室北京 100193)
(²中国农业科学院蔬菜花卉研究所北京 100081)
(³山东农业大学化学与材料科学学院泰安 271018)

收稿日期:2010-11-14 修回日期:2011-03-06 发布日期:2011-04-12
通讯作者: 凌云 E-mail:lyun@cau.edu.cn

Synthesis and Fungicidal Activities of Aryl Thiocarbamic Acid-5-aryl-2-furanmethyl Ester

Li Ying¹ Li Baoju² Yang Xinling¹ Shi Yanxia² Miao Hongjian¹ Ling Yun*^,1

(¹ Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193)
(² Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sci-ences, Beijing 100081)
(³ College of Chemistry and Material Science, Shandong Ag-ricultural University, Taian 271018)

Received:2010-11-14 Revised:2011-03-06 Published:2011-04-12

To find new pesticide lead compounds with high activity and low toxicity, chitin was chosen as the research target. 23 novel N-benzoyl-thiocarbamic-O-(5-aryl-2-furanmethyl) ester were designed and synthesized from substituted benzoic acid and 5-aryl-2-furanmethanol. Their structures were confirmed by IR, ¹H NMR and elemental analysis. The preliminary bioassay results indicated that some compounds showed obvious inhibition effects against Corynespora cassiicola, Botrytis cinereap-ers, Fusarium oxysporum, especially to Botrytis cinereapers in which most compounds showed higher inhibitory rate than control fungicide 40% WP dimethachlon.

Key words: benzoylureas, chitin, N-benzoyl-thiocarbamic-O-(5-aryl-2-furanmethyl) ester, fungicidal activ-ity

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LI Ying, LI Bao-Ju, YANG Xin-Ling, SHI Yan-Xia, MIAO Hong-Jian, LING Yun. Synthesis and Fungicidal Activities of Aryl Thiocarbamic Acid-5-aryl-2-furanmethyl Ester[J]. Chin. J. Org. Chem., 2011, 31(9): 1411-1418.

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取代苯甲酰胺基硫代甲酸-(5-取代苯基-2-呋喃)-甲酯的合成及杀菌活性

Synthesis and Fungicidal Activities of Aryl Thiocarbamic Acid-5-aryl-2-furanmethyl Ester

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