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Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (12): 2095-2101. Previous Articles     Next Articles

Original Articles

二芳醚基哌嗪类衍生物的合成及细胞毒活性研究

阳应华; 张丽娟; 杨雷香; 王晓雨; 巫秀美 ; 赵 昱*   

  1. (浙江大学药学院中药与天然药物研究室 杭州 310058)
  • 收稿日期:2008-02-29 修回日期:2008-06-01 发布日期:2008-12-28
  • 通讯作者: 赵 昱

Synthesis of Diaryl Ether Substituted Piperazine Derivatives and Their Cytotoxic Activities

YANG, Ying-Hua; ZHANG, Li-Juan; YANG, Lei-Xiang; WANG, Xiao-Yu ;
WU, Xiu-Mei ; ZHAO, Yu*
  

  1. (Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences,
    Zhejiang University, Hangzhou 310058)
  • Received:2008-02-29 Revised:2008-06-01 Published:2008-12-28
  • Contact: ZHAO, Yu

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Twenty-one new diaryl ether substituted piperazine derivatives were synthesized and their structures were confirmed by 1H NMR, ESI-MS and HRMS data. The preliminary biological activity tests showed that some of the title compounds had good activities. Compound 4i exhibited a potent cytotoxicity against the Eca109 and CNE cell lines with IC50 values of 7.13 and 4.54 μmol•L－1, respectively, which showed the similar activities to the positive control, cisplatin. Compound 5d also possessed an efficient cytotoxicity aganist CNE cell lines with an IC50 value of 8.49 μmol•L－1.