Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (01): 66-70. Previous Articles     Next Articles

Original Articles

新型脂肪族酯和磷酸酯共聚物的合成与表征

张世平; 宫 铭; 马佳妮 ; 韩 琳; 宫永宽*   

  1. (西北大学化学系 合成与天然功能分子化学教育部重点实验室 西安 710069)
  • 收稿日期:2007-12-14 修回日期:2008-07-10 发布日期:2009-01-20
  • 通讯作者: 宫永宽

Synthesis and Characterization of Novel Copolymers of Aliphatics Polyester and Polyphosphoester

Zhang, Shiping; Gong, Ming; Ma, Jiani; Han, Lin; Gong, Yongkuan*   

  1. (Key Laboratory of Synthetic and Natural Functional Molecule Chemistry, Ministry of Education,
    Department of Chemistry, Northwest University, Xi’an 710069)
  • Received:2007-12-14 Revised:2008-07-10 Published:2009-01-20
  • Contact: Gong, Yongkuan

To optimize the biomedical application of aliphatic polyester and polyphosphoester, a series of copolymers containing aliphatic polyester and polyphosphoester segments in the repeat units were synthesized via con-densation polymerization reaction with adipoyl chloride, ethyl dicholorophosphate and triethylene glycol as the beginning materials. The effects of reaction conditions on polymerization were studied and the structures of final polymers were characterized by 1H NMR, FT-IR and MALDI-TOF MS. Dynamic contact angle was used to characterize the surface capability of the polymers. The controlled release character of the copolymers was studied by a fluorescence method using neutral red as a model drug.

Key words: polyphosphoester, aliphatic polyester, dynamic contact angle, drug release, neutral red