Synthesis of 6－S－I(substituted triazolyl of tetrazolyl)－1，2：3， 4－di-O-isopropylidene-α-D-galactopyanoses

Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (2): 176-181. Previous Articles Next Articles

6－S－（取代的三或四唑杂环基）－1，2：3，4－二－O－异亚丙基－α-D吡喃型半乳糖的合成研究

张素娜;于建新;李中军;孙万赋;周蓉;张丽静;王瑞英;蔡孟深

北京大学药学院化学生物学系.北京(100083);新疆大学化学系,乌鲁木齐 (830046)

发布日期:2003-02-25

Synthesis of 6－S－I(substituted triazolyl of tetrazolyl)－1，2：3， 4－di-O-isopropylidene-α-D-galactopyanoses

Zhang Suna;Yu Jianxin;Li Zhongjun;Sun Wanfu;Zhou Rong;Zhang Lijing;Wang Ruiying;Cai Mengshen

Department of Chemical Biology,School of Pharmaceutical Sciences, Perking University,Beijing(100083);Department of Chemistry,Xinjiang University,Ulumqi(830046)

Published:2003-02-25

Abstract

By the nucleophilic substitution reaction of 6-O-tosyl-l,2:3,4-di-O- isopropylidene-a-Z)-galactopyranose (3) with some substituted 1, 2,4- triazole-3-thiols (4a ~ 4c) or 1, 2, 3,4-tetrazole-5-thiols (5a~5f), nine 6-S-(substituted triazolyl or tetrazolyl)-l,2 : 3,4-di-O- isopropylidene-a-D)-galactopyranoses (6a ~ 6i) were prepared in high yields. Their structures and configurations were analyzed and established by elemental analysis, IR, NMR, MS spectra.

Key words: PYRRODIAZOLE P;TETRAZOLE P;PYRANE P;GALACTOSE;NUCLEOPHILIC REACTION, SUBSTITUTION REACTION;ANTITUMOR DRUGS;CONFORMATION;ELEMENTAL ANALYSIS, IR;1HNMR

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Zhang Suna;Yu Jianxin;Li Zhongjun;Sun Wanfu;Zhou Rong;Zhang Lijing;Wang Ruiying;Cai Mengshen. Synthesis of 6－S－I(substituted triazolyl of tetrazolyl)－1，2：3， 4－di-O-isopropylidene-α-D-galactopyanoses[J]. Chin. J. Org. Chem., 2003, 23(2): 176-181.

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6－S－（取代的三或四唑杂环基）－1，2：3，4－二－O－异亚丙基－α-D吡喃型半乳糖的合成研究

Synthesis of 6－S－I(substituted triazolyl of tetrazolyl)－1，2：3， 4－di-O-isopropylidene-α-D-galactopyanoses

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