Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (10): 1091-1098. Previous Articles     Next Articles

抗癌核苷类似物

吴耀文;蒋宇扬;付华;杨杰;赵玉芬   

  1. 清华大学
  • 发布日期:2003-10-25

Nucleoside Analogues as Anticancer Agents

Wu Yaowen;Jiang Yuyang;Fu Hua;Yang Jie;Zhao Yufen   

  1. Key Laboratory of Bioorganic Phosphorus Chemistry, of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University
  • Published:2003-10-25

The recent progress of nucleoside analogues as anticancer agents is reviewed. The mechanisms for the action of these nucleoside analogues and drag metabolism are introduced. Especially the inosine 5'- monophosphate dehydrogenase (IMPDH) inhibitors are described. At last the relationship between the structure of nucleoside phosphoramidates and their anticancer activity is discussed.

Key words: nucleoside anticancer agent;NUCLEOSIDE;INHIBITOR;PHOSPHORAMIDIC ACID P, ACETOACETIC ACID P;ANTICARCINOGEN;PHARMACOLOGY;

CLC Number: