A series of N-( p-trifluromethyl) phenyl-α -aminophosphonates were synthesized by the Mannich-type reactions. The structures were established by elemental analysis, ~1H NMR, MS and X-ray diffraction analysis. The crystals of compound 4d are monoclinic, space group P2_1/c, with unit cell dimensions a = 1.1957(5) nm, b = 1.0664(5) nm, c = 1.5943(7) nm, α =90°, β = 97.623(8)°, γ = 90°, V = 2.0150(15) nm~3, Z=A. D_c = 1.336 Mg/m~3, μ = 0.189 mm~(-1), F(000) = 840. The final R = 0.0593, R_w = 0.1690 for 2862 unique reflections. In the tabacoo field test, the new compounds possess a high antiviral activity against TMV. The inhibitivity rate of 4d could reach 67.03 % at the concentration of 0.0005%.

Key words: PHOSPHOAMIDIC ACID P;PHOSPHONIC ACID ESTER;CRYSTAL STRUCTURE, TOBACCO MOSAIC VIRUS;BIOLOGICAL ACTIVITY