Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (05): 602-606. Previous Articles     Next Articles

Original Articles

一种可回收配体[QN(OH)2]2PYDZ在烯烃不对称双羟化及氨羟化反应中的应用

金瑛,姚志军,张生勇,姜茹,孙晓莉*   

  • 收稿日期:2006-05-29 修回日期:2006-09-01 发布日期:2007-05-10
  • 通讯作者: 孙晓莉

Application of Recyclable Ligand [QN(OH)2]2PYDZ to Asymmetric Dihy-droxylation and Asymmetric Aminohydroxylation of Olefins

JIN Ying, YAO Zhi-Jun, ZHANG Sheng-Yong, JIANG Ru, SUN Xiao-Li*   

  1. (Department of Chemistry, Fourth Military Medical University, Xi'an 710032)
  • Received:2006-05-29 Revised:2006-09-01 Published:2007-05-10
  • Contact: SUN Xiao-Li

A reusable free cinchona alkaloid derivative ligand was applied to asymmetric dihydroxylation (AD) of 9 olefins with 85%~>99% ee and 82%~91% yields. It was also applied to asymmetric aminohy-droxylation (AA) of 5 olefins with 76%~>99% ee and 50%~72% yields. Two different methods for recycling ligand were tried in AD and AA reactions, respectively. The results showed that these two methods were effective in recovering and reusing the ligand.

Key words: chiral aminoalcohol, AD reaction, chiral diol, AA reaction, recycle, reusable free ligand