Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (05): 678-681. Previous Articles     Next Articles

Reports

(S)-和(R)-普萘洛尔的不对称合成

王燕,沈大冬,朱锦桃*   

  1. (浙江理工大学化学系 杭州 310018)
  • 收稿日期:2006-06-20 修回日期:2006-09-28 发布日期:2007-05-10
  • 通讯作者: 朱锦桃*

Asymmetric Synthesis of S- and R-Propranolols

WANG Yan, SHEN Da-Dong, ZHU Jin-Tao*   

  1. (Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018)
  • Received:2006-06-20 Revised:2006-09-28 Published:2007-05-10
  • Contact: ZHU Jin-Tao

The asymmetric synthesis of propranolol, β-blocker inhibitor, was described. Highly enantioenriched (S)-epichlorohydrin and (R)-3-chloro-1,2-propanediol were obtained from the kinetic hy-drolysis resolution of racemic epichlorohydrin by chiral salen-CoIII complex. (S)-Epichlorohydrin was used as chiral reagent to synthesize (S)- and (R)- propranolols in yields of 80.9% and 74.5% with. higher than 99% ee.

Key words: (R)-propranolol, (S)-epichlorohydrin, asymmetric synthesis<, S)-propranolol