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Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (07): 1105-1114. Previous Articles Next Articles
Original Articles
曾程初* ; 牛丽亭; 平大为; 钟儒刚
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Zeng, Chengchu* ; Niu, Liting; Ping, Dawei; Zhong, Rugang
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According to the steric, electrostatic and H-bonding features of the CoMFA model which was stemmed from the investigation of 38 2-styrylquinoline derivatives, a series of 2-styrylquinoline-7-sulfonamide derivatives were synthesized and evaluated as potential HIV integrase inhibitors. The structures of all compounds were characterized by NMR, IR, ESI-MS and HRMS techniques.
Key words: 2-styrylquinoline-7-sulfonamide, Perkin reaction, HIV integrase inhibitor
Zeng, Chengchu* ; Niu, Liting; Ping, Dawei; Zhong, Rugang. Design and Synthesis of 2-Styrylquinoline-7-sulfonamide Derivatives as Potential HIV Integrase Inhibitors[J]. Chin. J. Org. Chem., 2009, 29(07): 1105-1114.
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