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Chin. J. Org. Chem. ›› 1989, Vol. 9 ›› Issue (3): 259-262. Previous Articles Next Articles
赵儒林;范昌烈;卓仁禧
发布日期:
ZHAO RULIN;FAN CHANGLIE;ZHUO RENXI
Published:
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Twenty new dipeptide 5-fluorouracilpropyl and -butyl ester hydrochlorides were prepared from 5-fluorouracilpropyl or -butyl esters of amino acids with N-protected amino acid anhydrides. The antitumor activities of five of them were tested against Ehrlich ascites carcinoma in mice. Phe-Gly-O-(CH2)3-5-fluorouracil and Val-Leu-O-(CH2)4-5-fluorouracil hydrochlorides showed an inhibition ratio of 89.4% and 86.8%, resp.
CLC Number:
Q51
R914
ZHAO RULIN;FAN CHANGLIE;ZHUO RENXI. Synthesis and antitumor activity of dipeptyl 5-fluorouracil-propyl (butyl)ester derivatives[J]. Chin. J. Org. Chem., 1989, 9(3): 259-262.
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